<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>ijcicr</PublisherName> <JournalTitle>International Journal of Clinical Investigation and Case Reports</JournalTitle> <PISSN>C</PISSN> <EISSN>l</EISSN> <Volume-Issue>Volume 2, Issue 2</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(Apr-June)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>2023</Year> <Month>05</Month> <Day>11</Day> </PubDate> <ArticleType>Medicine</ArticleType> <ArticleTitle>Centrally Thrombosed Renal Angiomyolipoma: A COVID-Induced Pathology?</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>0</FirstPage> <LastPage>0</LastPage> <AuthorList> <Author> <FirstName>Adrian A. Naoun*</FirstName> <LastName>(USA)</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI>10.55828/ijcicr-22-05</DOI> <Abstract>Renal angiomyolipomas (AMLs) are benign neoplastic entities paradigmatically composed of smooth muscle, blood vessels, and adipose tissue. The cornerstone of renal AML identification fundamentally entails imaging; however, findings may rarely resemble malignancy and subsequently obfuscate diagnosis. Compellingly, the comorbid effect of viral diseases such as COVID-19 on neoplasm integrity and morphology remains incompletely understood. The present case reports a 46-year-old female presenting with intermittent right flank pain persisting for three weeks. Preliminary sonographic studies revealed a predominantly echogenic, space-occupying lesion with well-defined margins in the right renal cortex undergoing angiogenesis. Shortly thereafter, the patient contracted COVID-19, and the right flank pain progressed to a debilitatingly constant nature described as sharp, stabbing, and aggravating to an eight on a scale of ten. Recovery was uncomplicated; however, the patient presented with mild thrombocytopenia. Contrast-enhanced CT scans elucidated a compelling hypodense mass center suggesting the presence of an encapsulated thrombus accompanied by further invasion of Morison’s pouch 25 days post-initial identification. Histopathological examination of the surgically excised specimen confirmed the likely diagnosis of a centrally thrombosed renal angiomyolipoma. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection may have ostensibly contributed to neoplasm morphology alterations and subsequent thrombosis, as intrinsic renal cell damage is well-documented in the literature. Consequently, clinicians must remain vigilant that radiographic abnormalities may emerge secondary to comorbid viral infections such as COVID-19 via incompletely understood mechanism(s).</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Angiomyolipoma,COVID</Keywords> <URLs> <Abstract>https://ijcicr.com/ubijournal-v1copy/journals/abstract.php?article_id=14559&title=Centrally Thrombosed Renal Angiomyolipoma: A COVID-Induced Pathology?</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>1. Rajebi, H. and V. Katabathina, Renal Angiomyolipoma: What the Radiologist Needs to Know. Contemporary Diagnostic Radiology, 2020. 43(14): p. 1-5. 2. Jinzaki, M., et al., Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management. Abdominal Imaging, 2014. 39(3): p. 588-604. 3. 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